Both receptors include at least three isotypes designated α, β, and γ, encoded by distinct genes ( Chambon, 1996 Amann et al., 2011). The biological effects of vitamin A are mediated through binding of their active metabolites (retinoic acid) to retinoic acid receptors (RARs) and/or retinoid X receptors (RXRs). Therefore, we are the first to present results describing the long-term dietary intake of VAE impairs spermatogenesis using a mouse model. Furthermore, we examined the effects of VAE on the expression of genes involved in retinoid signaling and spermatogenesis to determine the underlying molecular mechanisms. Sperm viability, motility, and morphology were also impaired in VAE mice. Daily sperm production in VAE testes was dramatically decreased compared to that in control testes. Testicular cross sections from control mice contained a normal array of germ cells, while the seminiferous tubules from VAE mice exhibited varying degrees of testicular degeneration. At 10 weeks of age, the retinol concentration in the testes of VAE mice was significantly higher than that of control mice. To examine the effects of VAE on spermatogenesis, we used ICR male mice fed with control (AIN-93G purified diet: 4 IU/g) diet or VAE (modified AIN-93G diet with VAE: 1,000 IU/g) diet for 7 weeks (from 3 to 10 weeks of age). The objective of this study was to investigate whether chronic intake of VAE diet causes arrest of spermatogenesis. However, there has been no clear understanding about the role of chronic intake of vitamin A excess (VAE) in spermatogenesis. Vitamin A deficiency causes early cessation of spermatogenesis, characterized by a marked depletion of germ cells. Vitamin B12 supplements can help increase ejaculate volume and sperm count.Vitamin A and its derivatives contribute to many physiological processes, including vision, neural differentiation, and reproduction. This can also reduce the risk of chromosomal abnormalities that could cause conditions such as Down syndrome. Similarly, folate supplements are associated with improved sperm count and concentration in semen. This may also be associated with better sperm morphology. Antioxidant supplements can help increase the concentration of sperm in semen and improve sperm motility. Regulating the functioning of enzymes needed for stem cell division and replicationĬan Dietary Supplements Affect Sperm Quality?ĭietary supplements can improve sperm quality.Maintaining stability in cell nuclei that contains DNA.Regulating the amount of oxygen consumed by sperm.Some of its most important functions are: Zinc plays multiple roles in sperm production. In addition, it has antioxidant properties that can help boost sperm health. Folateįolate plays a very important role in the synthesis of DNA cells by regulating the functioning of methionine and cysteine. Also, these vitamins improve sperm quality by protecting sperm from oxidative damage. They also help maintain genetic integrity and prevent mutations. Vitamins from the B group such as cobalamin and niacin help with multiplication and repair of DNA. Some of the most important nutrients and vitamins that facilitate the development of sperm cells are: B Group Vitamins The nutritional components of your diet affect sperm production is many ways. Similarly, antioxidants help prevent oxidative damage that may cause the death of sperm. Micronutrients and dietary vitamins also help with DNA repair and transcription. Thus, what a man eats and the nutrition he gets influences sperm production to a large extent. The nutrients required to synthesise DNA are largely derived from a person’s diet. The quantity and quality of sperm being produced depend on a man’s DNA structure.
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